You need to be paying attention to Ohio tech: December 2025

If you’ve follow my regular updates on LinkedIn or caught up with us at an OhioX event, you know I’m a firm believer in a simple truth: Ohio’s future is being built right now.

For years, we've talked about "potential." Today, we’re talking about results. From the $200 million life sciences expansion in New Albany to a billion dollar AI supercluster in Springfield, the scale of what’s happening across all 88 counties is unlike anything we've seen in Ohio in generations.

We're watching a historic "high-tech pivot" in real-time. Whether it’s a Dayton startup securing rare FAA waivers for autonomous flight, Cleveland companies redefining chronic pain treatment, or Columbus playing a leading role in powering the global AI race as a top-six data center market, the momentum is undeniable. But these headlines aren't just about big numbers and billion-dollar facilities—it’s about the people and the ideas moving our state forward.

As I like to say, you need to be paying attention to Ohio tech.

Here are some recent headlines...

Vultr to invest $1 billion in Ohio for AMD-Powered AI Supercluster.

The cloud infrastructure leader selected Clark County's Springfield for a 50-megawatt facility housing 24,000 AMD GPUs—a massive move for the state's digital compute power.

Ohio solidifies place as a leading hub in the global AI race.

With Columbus now the 6th largest data center market globally, the state anchors a Midwest pivot toward AI through billions in capital and semiconductor investment.

Digital health giant Hims & Hers invests $200 million to expand Ohio life sciences hub.

Breaking ground in 2026, this New Albany expansion adds 400 jobs and doubles the company's footprint for tech-enabled patient care.

Google-powered "STAR" Program graduates latest cohort to fuel Ohio’s building boom.

As Central Ohio’s digital infrastructure expands, Google’s STAR program is moving underrepresented local talent into high-demand careers.

Ohio companies surge in 2025 Deloitte Technology Fast 500 Rankings.

Massive revenue gains from Keyfactor, CHAMP Titles, and TradingView confirm Ohio software firms are now successfully competing on the national stage.

Columbus’ Paradigm Health redefines cancer research with $78 million raise.

By acquiring Flatiron Health's research unit, Paradigm creates the largest U.S. oncology research network to democratize access to life-saving therapies.

Dexa is soaring in the ‘Birthplace of Aviation’

Dayton-based Dexa has secured a rare FAA waiver for autonomous, beyond-line-of-sight flights, leveraging AI for 15-minute local delivery.

Dayton’s Niobium secures $23 million to scale quantum-resilient encryption.

Backed by JobsOhio and Rev1 Ventures, the startup is scaling hardware that allows high-speed computation on data while it remains fully encrypted.

Toledo AI startup DentalBee acquired by industry leader Overjet.

A major AI exit for Northwest Ohio as a local voice pioneer joins a global leader to create the first comprehensive clinical engine for patient records.

Ohio deploys ‘Eva,’ a first-of-its-kind AI assistant for election officials.

Available to all 88 counties, "Eva" gives officials instant, verified guidance on Ohio’s voting rules to speed up decision-making.

Fifth Third and Brex bring AI to modernize $5.6 billion in business banking.

This partnership applies AI-native finance to commercial spend, replacing legacy friction with intelligent automation.

Meet the Next25: A new generation reinvents Ohio’s innovation economy.

OhioX and OTN identified the top 25 innovators under 35—from AI to medtech—who are defining Ohio’s next chapter.

Beyond the Hype: Sarah Slavik on human-centric AI adoption.

SkillSpout COO Sarah Slavik warns that for Ohio business leaders, AI isn't just a headline—it’s a deadline.

Inside UC’s AI push: Cincinnati goes all-in on AI.

The University of Cincinnati is embedding artificial intelligence across teaching and research to move the campus to full "AI-readiness."

The O.H.I.O. Fund adds electric bus maker Endera to its portfolio.

From a plant in Ottawa, Endera is scaling production of vertically integrated electric shuttles to anchor the state's re-industrialization.

Edge Energy secures $3.5 million for EV charging expansion.

Cincinnati-based Edge Energy will accelerate deployment of technology that enables ultra-fast EV charging without costly grid upgrades.

Cleveland’s MorelandConnect launches “FOUNDATION” AI platform.

An AI platform for mid-market companies that unifies business data to help organizations adopt AI in weeks, not months.

Neuronoff raises $4.5 million for chronic pain treatment.

Cleveland-based Neuronoff is bringing its Injectrode—an injectable, drug-free pain treatment—to market by 2026.

Healthy Roster acquires Sway Medical.

Columbus-based Healthy Roster unites two sports medicine innovators into one digital platform for injury documentation.

Inside RWX’s bid to reinvent Docker containers.

Built in Ohio, RWX’s new container image builder attacks the slowest parts of shipping software to unlock faster, AI-driven development.

Hypersonics, AI, and Quantum: Inside OFRN’s $10.2 million R&D push.

Seven new partnerships bridge the gap between local labs and federal deployment for high-stakes defense challenges.

Akron’s Polymer Cluster invests in 7 new innovation projects.

Supported by an $8M funding pool, the hub is targeting the "valley of death" for hard tech like bio-dressings and recyclable films.

State of Ohio’s $2 billion jobs expansion plan.

Governor Mike DeWine announced 12 new projects expected to create over 1,100 jobs across data centers and digital health.

Marietta College opens Center for Appalachian Innovation.

A new state-supported hub focused on research and capacity-building across Appalachian Ohio.

Bridging AI and Quantum Computing.

MorelandConnect Chief AI Architect Caden Kacmarynski explains why a physics-first approach is key to the region's hybrid tech future.

Modern Government in Action: How Ohio is using AI to improve service.

Ohio Secretary of State Frank LaRose writes on leveraging innovation to deliver faster results for businesses and voters.

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Chris Berry is the President and CEO of OhioX, a statewide nonprofit trade association, and the publisher of Ohio Tech News. He leads a growing coalition of Fortune 500 companies, startups, tech SMBs, universities, and more building Ohio's tech hub. Connect with him on LinkedIn or X.